Baral, Kedar

Abstract

Aflatoxin M1 (AFM1) is the hydroxylated metabolite of aflatoxin B1 (AFB1) formed in the liver of mammals and subsequently excreted in breastmilk (BM) of mammals. Humans are exposed to AFM1 mainly through the consumption of aflatoxin contaminated milk and foods. Determining levels of AFM1 is of significant public health importance due to the risk of exposure to breastfeeding infants. The objective of this study is to determine the prevalence of AFM1 in BM and assess factors associated with BM AFM1 levels in mothers.

Abstract

Background

Naturally occurring aflatoxins may contribute to poor growth and nutritional statuses in children.

Objectives

We analyzed the relationship between contemporary and lagged aflatoxin exposure and 1) length-for-age z-score (LAZ); and 2) length, knee-heel length, stunting, weight-for-age z-score (WAZ), and weight-for-length z-score (WLZ).

Methods

Abstract

Background:

Abstract

A growing body of mainly cross-sectional evidence suggests an association between mycotoxins, particularly aflatoxin exposure, and poor linear growth in children. We describe the design and methods of a rigorous longitudinal birth cohort study aimed to deepen our understanding of this hypothesized relationship and to validate dried blood spots as a less invasive, low-cost collection method for venous blood samples. The AflaCohort study was conducted in Banke district of Nepal from 2015 to 2019.

Background

Aflatoxins are found in diverse foods widely consumed worldwide. This study investigated the association between aflatoxin exposure and (a) consumption of specific foods, (b) dietary diversity (DD), and (c) seasonality.

This study used maternal and newborn data from the AflaCohort Study, an ongoing birth cohort study in Banke, Nepal (n = 1621). Data on aflatoxin B1(AFB1)-lysine adducts in maternal serum were collected once during pregnancy (at mean ± SD: 136 ± 43 d of gestation). Maternal serum AFB1-lysine adduct concentration was measured via HPLC.

This poster shows data supporting the relationship between maize and groundnut consumption and aflatoxin levels in Nepalese women eating a rice-dominated diet.

This poster draws on data from a longitudinal birth cohort study conducted in Banke, and addresses food restrictions based on household data. Presented at the 5th Annual Scientific Symposium in Kathmandu, Nepal.

This poster details evidence gathered from a multi-year assessment of institutional/ individual collaboration and commitment to nutrition governance at sub-national levels in Nepal.