Biological Mechanisms

Assessing the Relationship of Aflatoxin Exposure and Stunting in Children 6-59 Months of Age in 10 Districts of Nampula Province, Mozambique

Publication Type

The aim of this study was to enumerate the serum aflatoxin B1 (AFB1) in children 6-59 months of age, and estimate its association with linear growth in these children. To accomplish this aim, the team conducted a cross-sectional study that focused on understanding the extent and level of aflatoxin exposure as measured through presence in a serum sample from children. We also studied the association between serum aflatoxin and chronic malnutrition (stunting), accounting for other risk factors. The specific objectives of this study include: 1.

Avaliação da Relação entre a Exposição à Aflatoxina e a Desnutrição Crónica em crianças dos 6 aos 59 meses em 10 Distritos na Província de Nampula, Moçambique (POR)

Publication Type

O objectivo principal deste estudo foi avaliar os níveis de aflatoxina B1 (AFB1) sérica em crianças de 6 a 59 meses de idade e estimar a sua associação com o crescimento linear nessas crianças. Para atingir esse objectivo, a equipa conduziu um estudo transversal que se focou em compreender a extensão e o nível de exposição à aflatoxina, determinando a sua presença em amostras de soro de crianças. Também se estudou a associação entre aflatoxina sérica e desnutrição crónica, considerando outros fatores de risco. Os objectivos específicos deste estudo incluem: 1.

Markers of Environmental Enteric Dysfunction Are Associated with Poor Growth and Iron Status in Rural Ugandan Infants

Publication Type

Abstract

Background

Environmental enteric dysfunction (EED), characterized by altered intestinal permeability/inflammation, microbial translocation, and systemic inflammation (SI), may be a significant contributor to micronutrient deficiencies and poor growth in infants from low-resource settings.

Objective

We examined associations among EED, SI, growth, and iron status at 6 mo of age.

Methods

Early Life Exposure to Mycotoxins and Child Linear Growth in Nepal: Methods and Design of a Prospective Birth Cohort Study

Publication Type

Abstract

A growing body of mainly cross-sectional evidence suggests an association between mycotoxins, particularly aflatoxin exposure, and poor linear growth in children. We describe the design and methods of a rigorous longitudinal birth cohort study aimed to deepen our understanding of this hypothesized relationship and to validate dried blood spots as a less invasive, low-cost collection method for venous blood samples. The AflaCohort study was conducted in Banke district of Nepal from 2015 to 2019.