Ghosh, Shibani

Association Between Bio-fortification and Child Nutrition Among Smallholder Households in Uganda

Publication Type

We explored the empirical relationship between bio-fortification and child nutrition in Uganda. The research expanded the traditional approach used to address child nutrition by including in the model a categorical dependent variable for a household growing bio-fortified crop varieties. We used three waves of panel data from the Feed. The Future Innovation Lab for Nutrition, collected from 6 districts in Uganda.

Markers of Environmental Enteric Dysfunction Are Associated with Poor Growth and Iron Status in Rural Ugandan Infants

Publication Type

Abstract

Background

Environmental enteric dysfunction (EED), characterized by altered intestinal permeability/inflammation, microbial translocation, and systemic inflammation (SI), may be a significant contributor to micronutrient deficiencies and poor growth in infants from low-resource settings.

Objective

We examined associations among EED, SI, growth, and iron status at 6 mo of age.

Methods

Early Life Exposure to Mycotoxins and Child Linear Growth in Nepal: Methods and Design of a Prospective Birth Cohort Study

Publication Type

Abstract

A growing body of mainly cross-sectional evidence suggests an association between mycotoxins, particularly aflatoxin exposure, and poor linear growth in children. We describe the design and methods of a rigorous longitudinal birth cohort study aimed to deepen our understanding of this hypothesized relationship and to validate dried blood spots as a less invasive, low-cost collection method for venous blood samples. The AflaCohort study was conducted in Banke district of Nepal from 2015 to 2019.

Relatively Low Maternal Aflatoxin Exposure Is Associated with Small-for-Gestational-Age but Not with Other Birth Outcomes in a Prospective Birth Cohort Study of Nepalese Infants

Publication Type

This study used maternal and newborn data from the AflaCohort Study, an ongoing birth cohort study in Banke, Nepal (= 1621). Data on aflatoxin B1(AFB1)-lysine adducts in maternal serum were collected once during pregnancy (at mean ± SD: 136 ± 43 d of gestation). Maternal serum AFB1-lysine adduct concentration was measured via HPLC.

Unsafe Drinking Water Is Associated with Environmental Enteric Dysfunction and Poor Growth Outcomes in Young Children in Rural Southwestern Uganda

Publication Type

Environmental enteric dysfunction (EED), a subclinical disorder of the small intestine, and poor growth are associated with living in poor water, sanitation, and hygiene (WASH) conditions, but specific risk factors remain unclear. Nested within a birth cohort study, this study investigates relationships among water quality, EED, and growth in 385 children living in southwestern Uganda. Water quality was assessed using a portable water quality test when children were 6 months, and safe water was defined as lacking Escherichia coli contamination.

Association between maternal aflatoxin exposure during pregnancy and adverse birth outcomes in Uganda

Publication Type

Aflatoxins are toxic metabolites of Aspergillus molds and are widespread in the food supply, particularly in low‐ and middle‐income countries (LMICs). Both in utero and infant exposure to aflatoxin B1 (AFB1) have been linked to poor child growth and development. The objective of this prospective cohort study was to investigate the association between maternal aflatoxin exposure during pregnancy and adverse birth outcomes, primarily lower birth weight, in a sample of 220 mother‐infant pairs in Mukono district, Uganda.